Corticosteroids decrease mRNA levels of SERCA pumps, whereas they increase sarcolipin mRNA in the rat diaphragm
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چکیده
منابع مشابه
Sarcolipin interaction with SERCA is distinct from Phospholamban; only Sarcolipin can promote uncoupling of the SERCA pump
SERCA pump activity is modulated by Phospholamban (PLB) and Sarcolipin (SLN) in cardiac and skeletal muscle. Recent data suggest that SLN could play a role in muscle thermogenesis by promoting uncoupling of the SERCA pump (Lee, A.G. (2002) Current opinion in structural biology 12(4):547-554 and Bal et al (2012) Nature Medicine 18(10):1575-1579) but the mechanistic details are unknown. To better...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2000
ISSN: 0022-3751,1469-7793
DOI: 10.1111/j.1469-7793.2000.t01-2-00387.x